Some ISO file and certain motherboard combination may reset USB host controller and IODD-2541.
IODD-2541 booting time is longer than iodd 2531(ZM-VE300).
And an error may occur in booting.
Please try one of the following solutions.
1. Change the setting to ODD-MODE
2. Downgrade to 51(XX) version from http://iodd.kr/wordpress/product/iodd-2541/
3. Use external power source to iodd 2541 with USB Y-Cable